![]() Methods We carried out a meta-analysis focusing on the relationship between VEGF-related gene polymorphisms and treatment. Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering AMD in a Spanish population. Aims The purpose of this study is to investigate whether gene polymorphisms of the vascular endothelial growth factor A (VEGF-A) and its receptor (VEGFR-2) have a pharmacogenetics effect on the anti-VEGF treatment for neovascular age-related macular degeneration (nAMD). However, analysis of VEGFR2 rs2071559 polymorphism shows that carriers of GG genotype are more frequent in subjects with AMD (p: 0.032 Odds Ratio(OR): 1.933 confidence interval (CI): 1.053-3.549), but, when corrected by Bonferroni testing, the result was found to be not significant. We did not find statistically significant differences in genotypic distribution of VEGF rs699947 and rs833061 polymorphisms between patients and controls. We studied VEGFA rs699947 and rs833061, and VEGFR2 rs2071559 polymorphisms using real-time PCR with TaqMan probes. The same locus was reported to be specific to the risk of wet AMD but not dry AMD in a casecontrol study as well. Moreover, variants in MMP9 were associated with progression of wet AMD but not dry AMD (Table 7.2). We also studied 91 healthy subjects matched by age. The variants in these two loci are common variants and these two loci were not reported in any AMD casecontrol genetics study. We obtained peripheral blood samples from 151 patients with diagnosis of exudative AMD. We have analysed if polymorphisms in genes coding for VEGFA and VEGFR are associated to susceptibility to suffer AMD in a cohort of Spanish subjects. Previous studies on the potential link between AMD and vascular endothelial growth factor (VEGFA) and vascular endothelial growth factor receptor (VEGFR) have yielded conflicting results. Increased angiogenesis plays a central role in AMD development. Age-related macular degeneration (AMD) is a multifactorial disease due to interaction between genetic and environmental factors.
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